Bayesian Gene Heritability Analysis

By Viola Fanfani (

The Bayesian Gene Heritability Analysis software (BAGHERA) estimates the contribution to the heritability of a trait/disease of all the SNPs in the genome (genome-wide heritability) and those nearby protein-coding genes (gene-level heritability).

BAGHERA requires only summary statistics from a Genome-wide Association Study (GWAS), LD scores calculated from a population matching the ethnicity of the GWAS study and a gene annotation file in GTF format.


Alongside BAGHERA, we are providing a snakemake workflow repository with sample data. workflow-baghera


BAGHERA is still under development, and a major refactoring will happen at some point. If you find a bug, please report it on GitHub.

Indices and tables